CMS Releases New MTF Resource; Reminders To Enroll

NCPA August 14, 2025

CMS has released a new one-page Medicare Transaction Facilitator Enrollment Quick Guide to the CMS Help Desk website under the Browse Resources section, available here. This resource is designed to assist pharmacies, other dispensing entities, and third-party support entities with the MTF enrollment process.

Staff from the Centers for Medicare & Medicaid Services (CMS) delivered a highly attended webinar on enrollment in the Medicare Transaction Facilitator. A playback of the webinar and more resources and NCPA advocacy can be found on NCPA's Inflation Reduction Act: Resources and Advocacy Page.

You have probably received an email CMS on enrolling in the MTF of the Medicare Drug Price Negotiation Program. If you are going to participate in any Medicare Part D network for next year, you must enroll in the MTF-DM to receive your manufacturer refund payments. We encourage you to become familiar with the process before enrolling. Here are some things to know:

  • You can watch an intro to the MTF on CMS's dispenser homepage here.

  • You can view an FAQ from CMS on the MTF here.

  • You can contact CMS at [email protected] with any questions.

  • Before enrollment, you should make sure your NCPDP profile is accurate and updated.

  • Before enrollment, pharmacies need to know which functions, such as central pay or reconciliation services, they want to assign to any third-party support entities such as PSAOs or reconciliation vendors.

  • During enrollment, pharmacies will need to sign a legal agreement, so proceed with caution and be sure to carefully review and have your legal counsel review.

  • During enrollment, identify as having “material cashflow concerns,” as manufacturers can provide pharmacies with a plan for mitigating their cashflow concerns.

There is no hard deadline to complete enrollment, and it will be available after January 2026. Enrollment will take approximately one hour, and you will have to provide banking information. We recommend beginning enrollment ASAP, since you will have to be enrolled to receive manufacturer refunds, and be able to review the individual manufacturer effectuation plans in September.

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